Induced pluripotent stem cell model of chronic myeloid leukemia revealed olfactomedin 4 as a novel therapeutic target in leukemia stem cells

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专利权人:

发明人:

Igor I. Slukvin,Kran Suknuntha

申请号：

US14251231

公开号：

US09381210B2

申请日:

2014.04.11

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Disclosed herein are compositions and methods to treat and reduce therapeutic resistance in chronic myelogenous leukemia. Also disclosed herein are methods to generate leukemia stem cell like cells (iLSCs) generated from CML patient-derived iPSCs, and methods for utilizing iLSCs in screens to identify modulators of CML drug resistance and gene targets that underlie CML drug resistance.

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中国工程科技知识中心

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