Electrosurgical lysing devices and related systems and methods. In some embodiments, the lysing device may comprise a lysing tip comprising a plurality of beads and at least one lysing member, such as a lysing rod, defining at least one lysing segment extending between each pair of adjacent beads. The at least one lysing member may extend through a tunnel extending at least partially through each of the plurality of beads so as to define the at least one lysing segment between each pair of adjacent beads.