Apparatus and method for effecting at least one first layer of at least one biological structure of an internal organ can be provided. For example, it is possible to utilize at least one structural arrangement which is configured to be inserted into or adjacent to the organ, and including at least one vacuum device which is configured to at least partially displaced the first layer from at least one second layer. The displacement of at least one portion of the first layer from the second layer can occurs solely due to an application of suction by the at least vacuum device on the at least one first layer. The displacement can further occur by an application of a force on the first layer. At least one structural further arrangement can also be used which is configured to damage, without removing, the at least one displaced portion of the first layer. A displacement of adjacent portions of the first layer from the second layer can be performed in the organ by of a translation and/or a rotation of the device along a surface of the structure(s).
