PROBLEM TO BE SOLVED: To provide a technique which can easily manufacture a reverse vesicle composition using an oil solution used for a cosmetic and the like.SOLUTION: A manufacturing method of a reverse vesicle composition comprises: a step in which a first isotropic solution is obtained by dissolving a bimolecular membrane component in a volatile solvent a step in which a second isotropic solution is obtained by mixing the first isotropic solution with an oil solution a step in which the volatile solvent is vaporized in the second isotropic solution and a step in which the reverse vesicle of the bimolecular membrane component is formed by vaporization of the volatile solvent.COPYRIGHT: (C)2015,JPO&INPIT【課題】化粧料等に用いられる油剤を用いて、逆ベシクル組成物を容易に製造する技術を提供することを課題とする【解決手段】本発明の逆ベシクル組成物の製造方法は、二分子膜成分を揮発性溶媒に溶解させて、第1の等方性溶液を得る工程と、前記第1の等方性溶液を油剤と混合し、第2の等方性溶液を得る工程と、前記第2の等方性溶液における前記揮発性溶媒を揮発させる工程と、揮発性溶媒の揮発により、前記二分子膜成分の逆ベシクルを形成させる工程とを含む。【選択図】図1