PROBLEM TO BE SOLVED: To provide a technique which can easily manufacture a reverse vesicle composition using an oil solution used for a cosmetic and the like.SOLUTION: A manufacturing method of a reverse vesicle composition comprises: a step in which an isotropic solution is obtained by mixing and heating a bimolecular membrane component and an oil solution a cooling step in which the isotropic solution is cooled and a step in which the reverse vesicle of the bimolecular membrane component is formed by the cooling.COPYRIGHT: (C)2015,JPO&INPIT【課題】化粧料等に用いられる油剤を用いて、逆ベシクル組成物を容易に製造する技術を提供することを課題とする【解決手段】本発明の逆ベシクル組成物の製造方法は、二分子膜成分及び油剤を混合し、加熱して等方性溶液を得る工程と、前記等方性溶液を冷却する冷却工程と、前記冷却により、前記二分子膜成分の逆ベシクルを形成させる工程と、を含む。【選択図】図1