PROBLEM TO BE SOLVED: To provide a sustained-release preparation that controls simultaneously the elution properties of a plurality of medicines having different characteristics.SOLUTION: A sustained-release preparation contains a sustained-release granule that has a nuclear particle containing two or more medicines that differ at least in water solubility, and, on the surface of the nuclear particle, a sustained-release coating containing an acrylic water-insoluble polymer, a cellulose water-insoluble polymer, glycerol fatty acid ester and talc.SELECTED DRAWING: None【課題】性質の異なる複数の薬物の溶出性を同一に制御した徐放性製剤の提供。【解決手段】少なくとも水に対する溶解性が相違する2種以上の薬物を含む核粒子表面に、アクリル系水不溶性高分子、セルロース系水不溶性高分子、グリセリン脂肪酸エステル及びタルクを含む徐放性皮膜を有する徐放性造粒物を含有する徐放性製剤。【選択図】なし
