HARTUNG PAUL D.,VALVO VINCENT,KERBAGE CHARLES,CAGLE GERALD D.,NILAN DENNIS J.
申请号：
NZ60725711
公开号：
NZ607257A
申请日:
2011.08.12
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a device for detecting an amyloid protein in an eye of a mammal, the device comprising: - a light source configured to emit light to illuminate the eye with at least one of a wavelength of light, a polarisation of light or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound, which has been introduced to the eye, when the amyloid-binding compound is bound to the amyloid protein, and specifically binding to the amyloid protein indicative of the amyloidogenic disorder； and - an optical unit configured to receive light including fluorescence produced as a result of the illumination of the eye and to determine a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based at least on the time decay rate； and - the device comprising a photo detector unit for detecting fluorescence emitted from the eye and a time correlation single photon count module receiving electrical signals from the photo detector unit indicative of photon counts of fluoresced light from the eye.
