Le Tiran, Arnaud,Le Diguarher, Thierry,Starck, Jérôme-Benoît,Henlin, Jean-Michel,Guillouzic, Anne-Françoise,De Nanteuil, Guillaume,Geneste, Olivier,Davidson, James Edward Paul,Murray, James Brooke,Che
申请号：
ES14178030
公开号：
ES2593417T3
申请日:
2014.07.22
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Phosphate compound of formula (I): ** Formula ** where: - X and Y represent a carbon atom or a nitrogen atom, it being understood that they cannot simultaneously represent two carbon atoms or two nitrogen atoms； - A1 and A2 together with the atoms that carry them, an Het heterocycle optionally substituted, aromatic or not, consisting of 5, 6 or 7 ring members, which may contain, in addition to the nitrogen represented by X or Y, of one to three heteroatoms independently selected from oxygen, sulfur and nitrogen, it being understood that the nitrogen in question may be substituted with a group representing a hydrogen atom, a linear or branched (C1-C6) alkyl group, or a -C (O group) ) -O-Alk in which Alk is a linear or branched (C1-C6) alkyl group, or A1 and A2 independently represent each other, a hydrogen atom, a linear or branched (C1-C6) polyhaloalkyl, a group linear or branched (C1-C6) alkyl, or a cycloalkyl, - T represents a hydrogen atom, a linear or branched (C1-C6) alkyl optionally substituted with one to three halogen atoms, a (C1-C4) alkyl group -NR1R2, or a (C1-C4) alkyl group -OR6, - R1 and R2 represent, independently To each other, a hydrogen atom or a linear or branched (C1-C6) alkyl group, or R1 and R2, together with the nitrogen atom that carries them, form a heterocycloalkyl, - R3 represents a (C1-C6) alkyl group ) linear or branched, linear or branched (C2-C6) alkenyl, linear or branched (C2-C6) alkynyl, cycloalkyl, cycloalkyl (C3-C10) linear or branched (C1-C6) alkyl, heterocycloalkyl, aryl or heteroaryl, being understood that one or more carbon atoms of these groups, or of their possible substituents, may be deuterated, - R4 represents a phenyl substituted in position for with a group of formula - OPO (OM) (OM '), -OPO (OM) (O-M1 +), -OPO (O-M1 +) (O-M2 +), -OPO (O -) (O-) M3 2+, - OPO (OM) (O [CH2CH2O] nCH3), or -OPO (O-M1 +) (O [CH2CH2O] nCH3), or R4 represents a pyrimidin-5-yl group, substituted in position for with a group of the formula -OPO
