Refers to a compound of formula I, where ra is c1-c6 alkyl, halogen n is 0 - 4 RB is c1-c6 alkyl, halogen n is 0 - 4 is 0 - 3 M1 M2 = 1 - 4 Xa XB is CH = CH, n = CH, CH = N X is n, CH, C - (Halogen) RC is H, alkyl substituted C1 - C6 or not, among others.Preferred compounds are: 3 - oxo - 3 - [4 - (7H pyrrolo [2,3-d] pyrimidin-4-yl) - 1.7 - diazaespiro [4,5] dec-1-yl] propionitrilo 3 - 3 - methyl - [6 - (7H pyrrolo [2,3-d] pyrimidine 4 - il) - 1.6 - diazaespiro [3,4] oct - triazin-1-yl] - 3 - oxopropionitrilo among others.These compounds are inhibitors of Janus kinase 2, useful in the treatment of organ transplant rejection, autoimmune disease, Allergic diseases, chronic myeloproliferative disease, rheumatoid arthritisREFERIDA A UN COMPUESTO DE FORMULA I, DONDE Ra ES ALQUILO C1-C6, HALOGENO n1 ES 0-4 Rb ES ALQUILO C1-C6, HALOGENO n2 ES 0-4 m1 ES 0-3 m2 ES 1-4 Xa=Xb ES CH=CH, N=CH, CH=N X ES N, CH, C-(HALOGENO) Rc ES H, ALQUILO C1-C6 SUSTITUIDO O NO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-OXO-3-[7-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1,7-DIAZAESPIRO[4,5]DEC-1-IL]PROPIONITRILO 3-[3-METIL-6-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1,6-DIAZAESPIRO[3,4]OCT-1-IL]-3-OXOPROPIONITRILO ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA JANUS 2 UTILES EN EL TRATAMIENTO DE RECHAZO DE TRASPLANTE DE ORGANOS, ENFERMEDAD AUTOINMUNE, ENFERMEDADES ALERGICAS, ENFERMEDAD MIELOPROLIFERATIVA CRONICA, ARTRITIS REUMATOIDEA
