THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
SANTA MARIA, PETER LUKE,YANG, YUNZHI PETER,KIM, SUNGWOO,DOMVILLE-LEWIS, CHLOE
申请号：
PH12015502577
公开号：
PH12015502577A1
申请日:
2015.11.13
申请国别(地区):
PH
年份:
2016
代理人:
摘要：
Compositions arid methods are provided for the generation or treatment of chronic tympanic membrane perforation by modulation of HB-EGF activity. In the methods of the invention, a chronically perforated tympanic membrane is topically contacted with an effective dose of heparin binding-epidermal growth factor, HB-EGF, or an agent having HB-EGF activity, for a period of time sufficient to provide for improved healing of the membrane perforation. In some embodiments the dose of HBEGF is provided in a sustained release formulation； in other embodiments regular administration of a non-sustained release formulation is provided. In some embodiments, a sustained release formulation is biodegradable. In other embodiments sustained release is provided by a device, e.g. a pump or other release device.
