THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
SANTA MARIA, Peter Luke,YANG, Yunzhi Peter,KIM, Sungwoo,DOMVILLE-LEWIS, Chloe
申请号：
USUS2014/033536
公开号：
WO2014/186075A3
申请日:
2014.04.09
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Compositions arid methods are provided for the generation or treatment of chronic tympanic membrane perforation by modulation of HB-EGF activity. In the methods of the invention, a chronically perforated tympanic membrane is topically contacted with an effective dose of heparin binding-epidermal growth factor, HB-EGF, or an agent having HB-EGF activity, for a period of time sufficient to provide for improved healing of the membrane perforation. In some embodiments the dose of HBEGF is provided in a sustained release formulation； in other embodiments regular administration of a non-sustained release formulation is provided. In some embodiments, a sustained release formulation is biodegradable. In other embodiments sustained release is provided by a device, e.g. a pump or other release device.L'invention concerne des compositions et des procédés pour la génération ou le traitement d'une perforation de la membrane du tympan chronique par modulation de l'activité de HB-EGF.
