DERIVES D'ACIDE CARBONIQUE SUBSTITUES PAR PYRAZOLYLE EN TANT QUE MODULATEURS DU RECEPTEUR DE LA PROSTACYCLINE PGI2 ADAPTES AU TRAITEMENT DE TROUBLES LE FAISANT INTERVENIR
TRAN, THUY-ANH,IBARRA, JASON B.,SHIN, YOUNG-JUN,ULLMAN, BRETT,ZOU, NING,ZENG, XI
申请号：
CA2744124
公开号：
CA2744124C
申请日:
2009.11.24
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Pyrazole derivatives of Formula la and pharmaceutical compositions thereofthat modulate the activity of the PGI2receptor. Compounds of the present invention and pharmaceutical compositionsthereof are directed to methods useful in the treatmentof: pulmonary arterial hypertension (PAH) and related disorders； plateletaggregation； coronary artery disease； myocardialinfarction； transient ischemic attack； angina； stroke； ischemia-reperfusioninjury； restenosis； atrial fibrillation； blood clot formationin an angioplasty or coronary bypass surgery individual or in an individualsuffering from atrial fibrillation； atherosclerosis；atherothrombosis； asthma or a symptom thereof； a diabetic-related disordersuch as diabetic peripheral neuropathy, diabeticnephropathy or diabetic retinopathy； glaucoma or other disease of the eye withabnormal intraocular pressure； hypertension； inflammation；psoriasis； psoriatic arthritis； rheumatoid arthritis； Crohn's disease；transplant rejection； multiple sclerosis； systemic lupuserythematosus (SLE)； ulcerative colitis； ischemia-reperfusion injury；restenosis； atherosclerosis； acne； type 1 diabetes； type 2diabetes； sepsis； and chronic obstructive pulmonary disorder (COPD).
