PROSTACYCLINE RECEPTOR MODULATING COMPOUNDS (PGI2), CRYSTALLINE FORM OF THE COMPOUNDS, PHARMACEUTICAL COMPOSITION, USES OF THE SAME AND PROCESS FOR THE PREPARATION OF THE COMPOSITION
Abu J. M. Sadeque,Bryan A. Kramer,Hanna L. Shyfryna,Ning Zou,Pureza Vallar,Thuy-Anh Tran,Weichao Chen,Young-Jun Shin
申请号：
BRPI0910391
公开号：
BRPI0910391A2
申请日:
2009.03.17
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
modulator compounds of the prostacyclin receptor (pgi2) crystalline form of said compounds, pharmaceutical composition, uses thereof and process for preparing said composition the present invention relates to amide derivatives of formula (xiiia) and pharmaceutical compositions thereof that modulate activity of the pgi2 receptor. the compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (pah)； idiopathic pah； family pah； pah associated with collagen vascular disease, congenital heart disease, portal hypertension, hiv infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (pvod) or pulmonary capillary hemangiomatosis (pch) ； pah with significant venous or capillary involvement； platelet aggregation； coronary artery disease； myocardial infarction； transient ischemic attack； angina； stroke； ischemia-reperfusion damage； restenosis； atrial fibrillation； formation of blood clot in an individual with angioplasty or coronary bypass surgery or in an individual suffering from atrial fibrillation； atherosclerosis； atherothrombosis； asthma or a symptom of it； a diabetes related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy； glaucoma or other eye disease with abnormal intraocular pressure； hypertension； inflammation； psoriasis； psoriatic arthritis； rheumatoid arthritis； Crohn's disease； transplant rejection； multiple sclerosis； systemic lupus erythematosus (sle)； ulcerative colitis； ischemia-reperfusion damage； restenosis； atherosclerosis； acne； type 1 diabetes； type 2 diabetes； sepsis； and chronic obstructive pulmonary disorder (copd).compostos moduladores do receptor prostaciclina (pgi2) forma cristalina dos referidos compostos, composição farmacêutica, usos dos mesmos e processo para preparação da referida composição a presente invenção refere-se a derivado
