POOLMAN JAN THEUNIS,JACQUEMYN BERT,ABBANAT DARREN ROBERT,YON PATRICIA IBARRA,HERMANS PETER WILHELMUS MARIA,KOWARIK MICHAEL THOMAS,WETTER MICHAEL LUKAS,KEMMLER STEFAN JOCHEN,HAUPTLE MICHA ANDRES,GAMBIL
申请号：
IN201837007461
公开号：
IN201837007461A
申请日:
2018.02.27
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
Compositions and methods are described for inducing an immune response against extra intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B O1A O2 and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A O2 O6A and O25B.
