Jan Theunis POOLMAN,Bert JACQUEMYN,Darren Robert ABBANAT,Patricia Ibarra YON,Peter Wilhelmus Maria HERMANS,Michael Thomas KOWARIK,Michael Lukas WETTER,Stefan Jochen KEMMLER,Micha Andres HÄUPTLE,Veroni
申请号：
US15754867
公开号：
US20180243393A1
申请日:
2016.08.24
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.
