The present invention concerns a combination of a retinoid and a diol and polyunsaturated fatty acid ester, a dermatological or dermocosmetic composition containing such a combination and use of same in the treatment of acne and the prevention of retentional lesions. The present invention also concerns a retinoid, optionally in combination with a diol and polyunsaturated fatty acid ester, for use in the prevention of retentional lesions.本發明關於一類視色素以及一種二醇和多不飽和脂肪酸酯的一組合物、一含有此一組合物的皮膚學的或皮膚化妝品的組成物以及它們在治療痤瘡和預防滯留性損傷的用途。本發明亦關於一類視色素選擇性地組合以一種二醇和多不飽和脂肪酸酯供使用在預防滯留性損傷。