Exendin-4 analogue pegylated with polyethylene glycol or derivative thereof, preparation method thereof, and pharmaceutical composition for preventing or treating diabetes, containing same as active ingredient
Lee, Sung Kwon,Kim, Won Bae,Lee, Seulki,Kim, Tae Hyung
申请号：
AU2012276478
公开号：
AU2012276478B2
申请日:
2012.06.28
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
The present invention relates to an exendin-4 analogue PEGylated with polyethylene glycol or a derivative thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating diabetes, containing the same as an active ingredient. According to the present invention, it is possible to increase the yield of a PEGylated exendin-4 analogue and to enhance the therapeutic effect of a drug through the selective PEGylation of cysteine using exendin-4 in which said cysteine (Cys) is introduced at position 40 of the C terminal, and thus it is possible to usefully employ the same in a composition for preventing or treating diseases caused by the hypersecretion of insulin.
