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EXENDIN-4 ANALOGUE PEGYLATED WITH POLYETHYLENE GLYCOL OR DERIVATIVE THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DIABETES, CONTAINING SAME AS ACTIVE INGREDIENT
专利权人:
Sung Kwon Lee
发明人:
Sung Kwon Lee,Won Bae Kim,Seulki Lee,Tae Hyung Kim
申请号:
US13882361
公开号:
US20130217622A1
申请日:
2012.06.28
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present disclosure relates to an exendin-4 analogue PEGylated with polyethylene glycol or a derivative thereof, a preparation method, and a pharmaceutical composition for prevention or treatment of diabetes containing the same as an active ingredient. According to the present invention, the yield of an exendin-4 analogue can be increased via the selective PEGylation by using exendin-4 in which a cysteine is introduced into #40 site of the C-terminal, and treatment effect of medications can be increased, so that the exendin-4 analogue can be usefully applied as a composition for prevention or treatment of diseases caused by insulin hypersecretion.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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