Glucagon peptides with increased GIP activity are provided, optionally with GLP-1 and/or glucagon activity. In some embodiments, C-terminally extended glucagon peptides comprising an amino acid sequence substantially similar to native glucagon are provided herein.本發明係提供具增加胃抑胜肽(GIP)活性之胰高血糖素胜肽,其視情況具有胰高血糖素樣肽-1(GLP-1)及/或胰高血糖素活性。於某些實施例中,本發明提供包含有實際上與天然胰高血糖素相似之一羧基端延伸之胰高血糖素胜肽。