Glucagon peptides that exhibit GIP agonist activity in addition to glucagon and/or GLP-1 activity are provided. Pharmaceutical compositions comprising such glucagon peptides and therapeutic methods of using such peptides are also provided.本發明提供除胰高血糖素及/或GLP-1活性外尚呈現GIP激動劑活性的胰高血糖素肽。亦提供包含此等胰高血糖素肽之醫藥組成物及使用此等肽之治療方法。