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NOUVEAUX COMPOSÉS CARBOXYLIQUES UTILISÉS COMME MODULATEURS DE ROR GAMMA
专利权人:
Glenmark Pharmaceuticals S.A.
发明人:
申请号:
EP16840923.3
公开号:
EP3341357A4
申请日:
2016.08.26
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
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