The invention reIates to compounds of formulawherein the substituents R1,R2 and R4 have the meaning as set forth and explained in thedescription of the invention, to processes for the preparation of these compounds,pharmaceutical compositions containing same, the use thereof optionally incombination with one or more other pharmaceutically active compounds for thetherapy of a disease which responds to an inhibition of protein kinase activity,especially a neoplastic disease, in particular leukaemia, and a method for thetreatment of such a disease.