Bonvini, Ezio,Moore, Paul A.,Li, Jonathan C.,Johnson, Leslie S.,Shah, Kalpana
申请号：
AU2018260975
公开号：
AU2018260975A1
申请日:
2018.11.09
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018260975A120181129.pdf#####Abstract of the Invention: The present invention relates to Tri-Specific Binding Molecules, which are multichain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Tri-Specific Binding Molecule is preferably characterized in possessing binding domains that permit it to immunospecifically bind to: (1) an epitope of a first Cancer Antigen, (2) an epitope of a second Cancer Antigen, and (3) an epitope of a molecule that is expressed on the surface of an immune system effector cell, and are thus capable of localizing an immune system effector cell to a cell that expresses a Cancer Antigen, so as to thereby facilitate the killing of such cancer cell.
