BONVINI EZIO,MOORE PAUL A,LI JONATHAN C,JOHNSON LESLIE S,SHAH KALPANA
申请号：
IN201617040522
公开号：
IN201617040522A
申请日:
2016.11.28
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Tri-Specific Binding Molecule is preferably characterized in possessing binding domains that permit it to immunospecifically bind to: (1) an epitope of a first Cancer Antigen, (2) an epitope of a second Cancer Antigen, and (3) an epitope of a molecule that is expressed on the surface of an immune system effector cell, and are thus capable of localizing an immune system effector cell to a cell that expresses a Cancer Antigen, so as to thereby facilitate the killing of such cancer cell.
