GE HEALTHCARE LIMITED;NIHON MEDI-PHYSICS CO., LTD.
发明人:
申请号：
EP01938456.9
公开号：
EP1292338B1
申请日:
2001.06.18
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
A stabilized radiopharmaceutical composition, a kit including same, and a method for making same, where the radiopharmaceutical is (i) susceptible to either reductive degradation or radiolysis and which includes a metal complex of a radionuclide with a ligand, (ii) a first stabilizer for the radiopharmaceutical which is an amino-substituted aromatic carboxylic acid or a salt, ester or amide thereof, and (iii) a second stabilizer for the radiopharmaceutical which is a diphosphonic acid or salt thereof. The first and second stabilizers are present in an amount effective to stabilize the radiopharmaceutical, and the radiopharmaceutical is not a metal complex of the diphosphonic acid.
