The present invention relates to a combination comprising (a) RAD001 or a pharmaceutically acceptable salt thereof and (b) BEZ235 or pharmaceutically acceptable salt thereof for simultaneous separate or sequential use for enhancement of an immune response a pharmaceutical composition comprising such combination a method of enhancing immune response in a subject comprising administration of said combination to a subject in need thereof use of such combination for preparation of a medicament for the enhancement of an immune response and a commercial package thereto.