FGF-2 VARIANTS HAVING N-TERMINAL DELETIONS AND INCREASED RECEPTOR SELECTIVITY AND USES THEREOF

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专利权人:

PROCHON BIOTECH LTD.;HEPACORE LTD.

发明人:

Avner Yayon,Eran Rom,Irina Chumakov,Sara Blumenstein

申请号：

US15839088

公开号：

US20180127475A1

申请日:

2017.12.12

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to the design, manufacture and use of fibroblast growth factor (FGF) polypeptides having improved receptor specificity. In particular, the invention relates to isolated FGF2 and FGF4 polypeptides comprising a truncated N-terminus and optionally N-terminal amino acid substitutions. The present invention provides polypeptides, nucleic acids encoding the polypeptides, compositions comprising same and methods for use thereof.

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中国工程科技知识中心

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