This invention also regards the hyaluronic acid nano- particle for dosage of the active ingredient of 1 kinds little. The nano- particle which is due to this invention becomes, the hyaluronic acid of salt shape, the correct electric charge polymer, the poly- anionic salt and even when including the active ingredient of 1 kinds little. The method of obtaining the above-mentioned nano- particle manufactures the aqueous solution of the hyaluronic acid salt, manufactures the aqueous solution of the cation characteristic polymer, agitates mixes these solutions the poly- anionic salt in addition to the solution of the hyaluronic acid salt, consists of the fact that the nano- particle is formed, the active ingredient the early solution on the one hand or makes the suspensoid of the nano- particle melt which is obtained, makes the nano- particle absorb. In addition as for this invention, including the above-mentioned nano- particle, it regards the medicine and the cosmetics composition which become.本発明は、少くとも1種の活性成分の投与用のヒアルロン酸ナノ粒子に関する。本発明によるナノ粒子は、塩形のヒアルロン酸、正荷電ポリマー、ポリアニオン塩および少くとも1種の活性成分を含んでなる。上記ナノ粒子を得る方法は、ヒアルロン酸塩の水溶液を調製し、カチオン性ポリマーの水溶液を調製し、ポリアニオン塩をヒアルロン酸塩の溶液に加え、これら溶液を攪拌混合し、ナノ粒子を生成することからなり、活性成分は、初期溶液の一方にまたは得られたナノ粒子の懸濁液に溶解させ、ナノ粒子に吸収させる。本発明はまた、上記ナノ粒子を含んでなる医薬および化粧品組成物に関する。
