LEE, STEPHEN C.,LU, WU,BRILLSON, LEONARD JACK,HADLEY, GREGG A.,ADAMS, PATRICK,PELLETIER, RONALD P.,BERGER, PAUL RAYMOND
申请号:
CA2862468
公开号:
CA2862468A1
申请日:
2013.01.23
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
Disclosed are field effect transistor-based (FET-based) sensors for the rapid and accurate detection of analytes both in vivo and in vitro. The FET-based sensors can include a substrate, a channel disposed on the substrate, a source electrode and a drain electrode electrically connected to the channel, and a recognition element for an analyte of interest immobilized on the surface of the channel via a linking group. The distance between the recognition element and the channel can be configured such that association of the analyte of interest with the recognition element induces a change in the electrical properties of the channel. In this way, an analyte of interest can be detected by measuring a change in an electrical property of the channel. Also provided are devices, including probes and multi-well plates, incorporating the FET-based sensors.