製造ＪＡＫ抑制劑之方法及相關中間化合物农业专利-农业学术服务平台

发明人:: ZHOU, JIACHENG,周家谦,周家謙,LIU, PINGLI,刘平里,劉平里,LIN, QIYAN,林琦彦,林琦彥,METCALF, BRIAN W.,梅特卡夫　布莱恩Ｗ,梅特卡夫　布萊恩Ｗ,MELONI, DAVID,美乐尼　大卫,美樂尼　大衛,PAN, YONGCHUN,潘永春,XIA, MICHAEL,加亚　麦可,加亞　麥可,LI, MEI,李梅,YUE, TAI-YU,梅特卡夫布莱恩W,梅特卡夫布萊恩W,美乐尼大卫,美樂尼大衛,加亚麦可,加亞麥可

摘要：: The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.本發明係關於製備式III對掌性取代之吡唑基吡咯并[2,3-d]嘧啶類及相關合成中間化合物之方法。此對掌性取代之吡唑基吡咯并[2,3-d]嘧啶類可作為蛋白質酪胺酸激酶(JAK)之Janus激酶族群之抑制劑用於治療炎性疾病、骨髓增生病症及其他疾病。