The present invention provides a pharmaceutical preparation for use by injection into the skin, wherein the pharmaceutical preparation is preparable by a production method comprising the steps of providing a liquid collected from an organism, which liquid comprises cellular constituents of blood, providing a vessel or containment means, said vessel or containment means having an internal surface, and contacting said liquid with said vessel or containment means, wherein (a) said production method further comprises the step of incubating said liquid in said vessel or containment means for an incubation time, and optionally removing cellular constituents of said liquid after said incubation. (b) said liquid comprises exosmes, and said production method further comprises the steps of concentrating said exosomes and optionally removing cellular constituents of said liquid after said concentration, or the step of isolating said exosomes, or (c) said production method further comprises the step of avoiding incubation of said liquid, and the step of removing cellular constituents of said liquid contacted with said vessel or containment means.本發明提供一種藉由注射至皮膚中使用的醫藥製劑，其中該醫藥製劑可藉由包括以下步驟的製造方法來製備：提供收集自生物體之液體，該液體包含血液之細胞成分；提供器皿或容納構件，該器皿或容納構件具有內表面；及使該液體與該器皿或容納構件接觸，其中(a)該製造方法進一步包括於該器皿或容納構件中培養該液體持續一段培養時間，及視需要於該培養後移除該液體之細胞成分的步驟，(b)該液體包含胞外體，且該製造方法進一步包括濃縮該等胞外體及視需要於該濃縮後移除該液體之細胞成分的步驟，或分離該等胞外體之步驟，或(c)該製造方法進一步包括避開該液體之培養的步驟，及移除與該器皿或容納構件接觸之該液體之細胞成分的步驟。
