Harry E. Gruber,Douglas J. Jolly,Derek G. Ostertag,Ryan S. Burnett,Amy H. Lin,Tiffany Huang,Joan M. Robbins
申请号:
US13882487
公开号:
US20130323301A1
申请日:
2011.10.31
申请国别(地区):
US
年份:
2013
代理人:
摘要:
This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.