Joan M. Robbins,Douglas J. Jolly,Derek G. Ostertag,Tiffany Huang,Harry E. Gruber
申请号：
US14137803
公开号：
US20140178340A1
申请日:
2013.12.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This disclosure relates to a combination therapy of chemotherapeutics and/or radiosensitizing agents with a replication competent viral vectors for treating cell proliferative disorders and chemotherapeutic treatments. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.
