The present invention provides methods compositions and combinations for treating cancer via combined use of a compound of formula I or a pharmaceutically acceptable salt ester solvate and/or prodrug thereof wherein A Q n m R7 R8 V X1 X2 X3 X4 X5 X6 and X7 are as defined herein and at least one therapeutically active agents selected from immunotherapeutics anticancer agents and anti-angiogenics.
