A controlled release pharmaceutical composition is disclosed, which comprises: a drug core comprising 10-50 mg of Carvedilol or a pharmaceutical acceptable salt thereof, and a first pharmaceutical acceptable polymer, wherein a content of the first pharmaceutical acceptable polymer is 0.01-50% based on a total weight of the drug core； and a controlled release coating layer covering the drug core and comprising a second pharmaceutical acceptable polymer. In addition, a method for manufacturing the aforementioned controlled release pharmaceutical composition is also disclosed.本發明係關於一種緩釋醫藥組成物及其製備方法，其中緩釋醫藥組成物包括：一藥核，包含：10毫克至50毫克的卡維地洛或其醫藥上可接受性鹽、以及一第一藥學可接受聚合物，其中該第一藥學可接受聚合物之含量係佔該藥核之總重量之0.01%至50%；以及一緩釋塗層，包覆該藥核且包含：一第二藥學可接受聚合物。
