Disease in food crops caused by fungal pathogens is a major concern to the agricultural industry, with annual losses typically in the billions of dollars. Fusarium graminearum, also known as Gibberella zeae, is known to cause, among other diseases, headblight disease in wheat and stalk and ear rot in maize. Disease caused by Fusarium graminearum has proven to be a difficult disease to manage because of limitations of control options. Disclosed herein are nucleic acid sequences which have been proven to provide corn and soybean with resistance to Fusarium graminearum. Also disclosed herein are methods of using the nucleic acid sequences, and plants comprising the nucleic acid sequences.