FERNANDEZ MOLINA, LUIS ENRIQUE,弗南德兹莫里纳 路易斯,弗南德茲莫里納 路易斯,SANCHEZ RAMIREZ, BELINDA,桑乔斯拉米瑞兹 布琳达,桑喬斯拉米瑞茲 布琳達,FERNANDEZ GOMEZ, AUDRY,法瑞狄兹 奥拙,法瑞狄茲 奧拙,BERGADO BAEZ, GRETCHEN,博加多贝 格雷琴,博加多貝 格雷琴,MESA PARDILLO, C
申请号：
TW107137740
公开号：
TW201927804A
申请日:
2018.10.25
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
This invention describes ways of obtaining nano-particulated adjuvants formed by different synthetic variants of GM3 ganglioside. Depending on the fine structure of the fatty acid in the ceramide of the synthetic GM3, said adjuvants are able to stimulate specifically and in a specialized way the humoral or cellular immune response against accompanying antigens. Particularly, this invention provides immunogenic vaccine compositions that comprise peptides, polypeptides or proteins and the aforementioned nanoparticles, which are formed through the dispersion of hydrophobic proteins of the outer membrane complex (OMC) ofNeisseria meningitidisin solutions containing fully synthetic variants of the GM3 ganglioside.本發明描述獲得藉由GM3神經節苷脂之不同合成變體所形成之奈米粒子化佐劑的方法。取決於合成的GM3之神經醯胺中的脂肪酸之細微結構，該佐劑可用特化方式特異性刺激針對伴隨的抗原之體液或細胞免疫反應。特別地，本發明提供免疫原性疫苗組成物，其包括胜肽、多肽或蛋白質以及上述奈米粒子，其是經由將腦膜炎雙球菌的外膜複合物(outer membrane complex，OMC)的硫水性蛋白質分散在含有GM3神經節苷脂之完全合成變體之溶液中而形成。
