BIONTECH RNA PHARMACEUTICALS GMBH;TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GEMEINNÜTZIGE GMBH
发明人:
MICHAEL KOSLOWSKI,SEBASTIAN KREITER,TANA OMOKOKO,UGUR SAHIN,MUSTAFA DIKEN,JAN DIEKMANN,CEDRIK BRITTEN,JOHN CASTLE,MARTIN LÖWER,BERNHARD RENARD,JOHANNES HENDRIKUS DE GRAAF
申请号：
PT12723117
公开号：
PT2714071T
申请日:
2012.05.23
申请国别(地区):
PT
年份:
2019
代理人:
摘要：
The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient； and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
