Ugur Sahin;Sebastian Kreiter;Mustafa Diken;Jan Diekmann;Michael Koslowski;Cedrik Britten;John Christopher Castle;Martin Lower;Bernhard Renard;Tana Omokoko;Johannes Hendrikus De Graaf
发明人:
Ugur Sahin,Sebastian Kreiter,Mustafa Diken,Jan Diekmann,Michael Koslowski,Cedrik Britten,John Christopher Castle,Martin Lower,Bernhard Renard,Tana Omokoko,Johannes Hendrikus De Graaf
申请号：
US14119348
公开号：
US10738355B2
申请日:
2012.05.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient； and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.
