“Antibodies, polynucleotide, vector, cell, antibody expression method, kit, method for detecting the presence or level of human or monkey pd-l1 in a sample, method of identifying an individual with a disorder, method for monitoring therapeutic response, pharmaceutical composition, method for treating a condition in a subject and antibody use
OPEN MONOCLONAL TECHNOLOGY, INC.;WUXI BIOLOGICS (SHANGHAI) CO. LTD.
发明人:
JING LI,YONG ZHENG,ZHISHENG CHEN
申请号：
BR112018002428
公开号：
BR112018002428A2
申请日:
2016.08.05
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present disclosure provides monoclonal antibodies against programmed cell death linker protein 1 (pd-11), which can block the binding of pd-11 to pd-1 and thereby block the inhibitory function of pd-11 on cells. t expressing pd-1. The antibodies of the disclosure provide very potent agents for the treatment of multiple cancers by modulating human immune function.a presente divulgação provê anticorpos monoclonais contra a proteína 1 ligante de morte celular programada 1 (pd-l1), que pode bloquear a ligação do pd-l1 à pd-1 e, desse modo, bloquear a função inibidora do pd-l1 sobre células t que expressam pd-1. os anticorpos da divulgação fornecem agentes muito potentes para o tratamento de múltiplos cânceres pela modulação da função imune humana.
