Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I):wherein R1, R2, L1, and L2are as defined herein.本文描述使用式(I)化合物調節受試者之PKM2活性的方法。此等化合物由式(I)表示:其中R1、R2、L1及L2如本文所定義。