The present invention relates to compounds of general formula I, wherein the groups R1, R2, L1, L2, U and B are as defined in the application, which have valuable pharmacological properties, and in particular modulate the activity of the MCH receptor.本發明係關於通式I化合物,其中基團R1、R2、L1、L2、U及B係如本申請案中所定義,該等化合物具有有價值之藥理學特性,且具體而言調節MCH受體之活性。