PURPOSE: A silk peptide composition is provided to offer high molecular weight of silk peptide composition which is merely absorbed into human body and has complex function of improving hypercholesterolemia and hyperlipidemia by using silk protein.CONSTITUTION: A functional food composition is produced by decomposing silk protein and includes 10000-100000 weight-average molecular weight of silk peptides as an active ingredient. The improvement on blood lipid related diseases is improvement of total cholesterol in blood, improvement of LDL(low density lipoprotein) cholesterol in blood or improvement of triglyceride in blood. The silk protein is silk fibroin. The silk protein decomposition is performed by a decomposition method selected from a group consisting of decomposition in calcium salt solution, acidic hydrolysis, decomposition by a mixture solution of calcium salt and ethanol and a combination thereof. The calcium salt is calcium chloride. The calcium salt removal is selected from a method consisting of dialysis, ultrafiltration, gel chromatography, electric desalting and a combination thereof.COPYRIGHT KIPO 2013본 발명은 혈중 콜레스테롤 및 혈중 중성지방을 낮추는 개선 효과가 있는 고분자 실크 펩타이드의 구성물에 관한 것으로, 실크(견사)를 산 가수분해 방법 또는 염화칼슘을 이용하여 가수분해하여 동결 건조한 후, 분말상으로 제조한 고분자 실크 펩타이드 조성물로써, 본 발명의 실크 펩타이드의 분자량은 10,000~50,000 으로 체내에서 흡수되지 않아 혈중 콜레스테롤 및 혈중 중성지방을 낮추는 기능성 식품 또는 의약품으로 개발하거나 각 성분에 대한 활성물질의 개발에 기여할 수 있다.
