Vancomycin-containing compositions substantially free of precipitation after at least about 12 months of storage at refrigerated or ambient conditions are disclosed. The compositions include vancomycin or a pharmaceutically acceptable salt thereof a polar solvent including propylene glycol, polyethylene glycol and mixtures thereof lactic acid, a lactate salt, or mixtures thereof and optionally, a pH adjuster in an amount sufficient to maintain a pH of the compositions at from about 3 to about 8.
