PROBLEM TO BE SOLVED: To provide a new compound having activity enhancement action for antifungal agents such as polyene macrolide-based drug and azole-based drug.SOLUTION: The compound is produced by incubating simplicillium sp-FKI-4981 which is a microbe having capability of producing FKI-4981B substance expressed by formula [I], and has activity enhancement action for antifungal agent such as polyene macrolide-based drug and azole-based drug, so that the compound works on a number of fungal infectious diseases including deep mycosis at a low concentration and in a short period, it is useful for reducing the appearance frequency of resistant bacteria and also utility for tolerance is expected.COPYRIGHT: (C)2012,JPO&INPIT【課題】ポリエンマクロライド系薬剤、アゾール系薬剤等の抗真菌剤の活性増強作用を有する新規化合物とその製造方法の提供。【解決手段】下記式[I]で表される、FKI-4981B物質を生産する能力を有する微生物であるシンプリシリウム・エスピーFKI-4981の培養により製造され、ポリエンマクロライド系薬剤、アゾール系薬剤等の抗真菌剤の活性増強作用を有することから、深在性真菌症をはじめとする多くの真菌感染症に対して、低濃度、短期間で作用し、耐性菌出現頻度の低減に有用であり、耐性克服に対する有用性も期待される化合物。【選択図】なし
