An apparatus for spectroscopic evaluation of a subjects body fluids may be used at the interstitial region adjacent to or in between a subjects extremities using a spectroscopic probe. The spectroscopic probe may possess movements such as rotational, translational, and/or vertical freedom necessary for the probe to contact the subjects tissue at a consistent angle and pressure while accommodating the different size of the subjects extremities, and may be housed in a device optimized for attaining reproducible blood flow to the region of the subject that is measured, and for minimizing the effects of the housing pulling, stretching, pressing, compressing the subjects skin. A pressure sensor may be used to ensure that measurements are takien at an optimal pressure. A touch sensor may be used to activate as system and/or to ensure flushness.an apparatus for spectroscopic evaluation of a subjects body fluids may be used to the interstitial region adjacent two or in between a subjects extremities using a spectroscopic probe.the spectroscopic probe may possess movements such as rotational, translational, and \/ or vertical freedom necessary for the probe to contact the subjects tissue to a consistent angle and pressure while accommodating the different size of the subject s extremities, and may be housed in a device opti mized for attaining reproducible blood flow to the region of the subject that is measured,and for minimizing the effects of the housing pulling, stretching, pressing, compressing the subjects skin. a pressure sensor may be used to ensure that measurements are takien to an optimum pressure. a touch sensor may be used to activate aa system and \/ or to ensure flushness.