ECOLE NORMALE SUPÉRIEURE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人:
PROCHIANTZ, ALAIN,DI NARDO, ARIEL,BEURDELEY, MARINE,HENSCH, TAKAO K.
申请号：
ES10704386
公开号：
ES2471458T3
申请日:
2010.01.19
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Cellular targeting polypeptide, characterized in that it is defined by the sequence B1B2X1B3B4X2B5X3X4X5X6B6X7X8X9 (SEQ ID No. 1), in which: B1, B2, B3, B4, B5 and B6 independently represent arginine or lysine； X1 and X8 independently represent asparginine or glutamine； X2 represents aspartic acid or glutamic acid； X3, X4 and X6 independently represent threonine or serine； X5 represents phenylalanine, tyrosine or tryptophan； X7 represents alanine or glycine； X9 represents leucine, isoleucine or valine. and because when it is placed in the presence of retinal cells, it specifically binds to ganglionic neurons and bipolar neurons.Polipéptido de direccionado celular, caracterizado porque se define mediante la secuencia B1B2X1B3B4X2B5X3X4X5X6B6X7X8X9 (SEC ID nº 1), en la que: B1, B2, B3, B4, B5 y B6 representan, independientemente, arginina o lisina； X1 y X8 representan, independientemente, asparginina o glutamina； X2 representa ácido aspártico o ácido glutámico； X3, X4 y X6 representan, independientemente, treonina o serina； X5 representa fenilalanina, tirosina o triptófano； X7 representa alanina o glicina； X9 representa leucina, isoleucina o valina. y porque cuando se pone en presencia de células retinianas, se une específicamente a las neuronas ganglionares y a las neuronas bipolares.
