Arizona Board of Regents on Behalf of Arizona State University
发明人:
Mason Hugh,Arntzen Charles,Rosenthal Sun Hee,Winkle Sean,Diamos Andrew
申请号：
US201414762128
公开号：
US10125373(B2)
申请日:
2014.01.22
申请国别(地区):
美国
年份:
2018
代理人:
Polsinelli PC
摘要：
A single vector or multiple separate vectors that contain two or more non-competing replicons for transient expression of the heavy and light chains of Rituximab in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures to optimize the expression is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of the multi-replicon single vector system for producing Rituximab in plant cells.
