Provided is a transdermal preparation having low skin irritation as well as a sufficient skin permeability rate of donepezil, which comprises one or more drugs selected from donepezil and pharmaceutically acceptable salts thereof. Also provided are a manufacturing method thereof, and a method for reducing skin irritation of a transdermally absorbable donepezil-containing preparation. An embodiment is a transdermal preparation comprising one or more drugs selected from donepezil and pharmaceutically acceptable salts thereof, and a skin irritation-reducing agent.本發明係以提供對皮膚的刺激性低，且含有1種以上選自具多奈派齊之充分的皮膚滲透速度之多奈派齊，及其藥學上許可之鹽之藥物的經皮吸收製劑，及其製造方法，以及降低含有多奈派齊的經皮吸收製劑對皮膚的刺激之方法為目的。本發明之一實施方式係為一種經皮吸收製劑，其係含有1種以上選自多奈派齊及其藥學上許可之鹽之藥物，以及降低皮膚刺激劑。
