ЧЕТТИБИ Салах (GB),НЬЮТОН Бен (GB),СОЛБАККЕН Магне (NO)
申请号：
RU2011149392/15
公开号：
RU2011149392A
申请日:
2010.06.10
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method for determining the presence, localization and / or amount of fibrogenic tissue in a subject’s liver, comprising the steps of: (1) introducing a detectable amount of a radioactive indicator of Formula I for positron emission tomography (PET) to said subject； (2) allowing a radioactive indicator for PET from step (1) to contact any fibrogenic tissue in the specified liver； (3) detect with PET the signals emitted by the associated radioactive indicator for PET from step (2)； and (4) creating an image typical of the localization and / or number of these signals； where the specified radioactive indicator for PET has Formula I: where one of Z and Z is a group containing F, and the other of Z and Z is hydrogen； each of W and W independently represents a bivalent linker moiety or Formulas Ia: where n is an integer from 1 to 10； R is C1-6 alkylene, Soxoalkylene, Soxaalkylene or Scarbonyl-substituted oxaalkylene； the dotted line represents the point of attachment to either Z or Z, or Formula I (b): where the double bond on the right represents the point of attachment to either Z or Z.2. The method according to claim 1, wherein said group of Formula I containing F is [F] fluorophenyl. The method according to claim 1, where Z in Formula I represents the specified group containing F.4. The method according to claim 1, where n in Formula Ia is from 3 to 5.5. The method of claim 1, wherein W is a bivalent linker of Formula Ib. 6. The method according to claim 1, wherein R in Formula Ia is Soxaalkylene. The method of claim 6, wherein R4 is Coxaalkylene. The method according to claim 7, where R is —CH — O — .9. The method according to claim 1, where1. Способ определения присутствия, локализации и/или количества фиброгенной ткани в печени субъекта, включающий следующие стадии, на которых:(1) вводят указанному субъекту обнаружимое количество радиоактивного индикатора Формулы I для позитронно-эмиссионной томографии (PET)；(2) позволяют введенному радиоактивному индикатору д
